Neuronal Firing Sensitivity to Morphologic and Active Membrane Parameters
نویسندگان
چکیده
منابع مشابه
Neuronal Firing Sensitivity to Morphologic and Active Membrane Parameters
Both the excitability of a neuron's membrane, driven by active ion channels, and dendritic morphology contribute to neuronal firing dynamics, but the relative importance and interactions between these features remain poorly understood. Recent modeling studies have shown that different combinations of active conductances can evoke similar firing patterns, but have neglected how morphology might ...
متن کاملTailoring inputs to achieve maximal neuronal firing
We consider the constrained optimization of excitatory synaptic input patterns to maximize spike generation in leaky integrate-and-fire (LIF) and theta model neurons. In the case of discrete input kicks with a fixed total magnitude, optimal input timings and strengths are identified for each model using phase plane arguments. In both cases, optimal features relate to finding an input level at w...
متن کاملA neuronal morphologic type unique to humans and great apes.
We report the existence and distribution of an unusual type of projection neuron, a large, spindle-shaped cell, in layer Vb of the anterior cingulate cortex of pongids and hominids. These spindle cells were not observed in any other primate species or any other mammalian taxa, and their volume was correlated with brain volume residuals, a measure of encephalization in higher primates. These obs...
متن کاملTime Cognition: Entangled Neuronal Firing
The neuroscience of time frequently focuses on either measuring short time intervals (sensory timing) or reproducing them (motor timing); during cognition, the two are integrated. New experiments using a combined sensory and motor timing task suggest that neuronal firing during the sensory and motor phases are linked.
متن کاملModification of acetylcholine sensitivity of neuronal membrane by presynaptic stimulation.
The action of electrical stimulation of one of the pallial nerves on the sensitivity of the bursting RPa1 neuron of Helix pomatia to acetylcholine (ACh) was investigated. The depolarizing effect of ACh was significantly decreased by presynaptic stimulation. Stimulation leads also to an attenuation of the ACh-induced increase in membrane conductivity. The effect of stimulation on the ACh evoked ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS Computational Biology
سال: 2008
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.0040011